Included in the lists of the Rolli from 1588, the present palace is the result of an 18th-century extension by Ticino architect Gregorio Petondi starting in 1775.

Passed into the ownership of the Lomellini family and finally to the Doria Lamba family, who still own it today, the building is the result of a long design process that changed along with the development of operations for the opening of Strada Nuovissima, today Via Cairoli, which took place between 1778 and 1786 by Petondi himself.

The palace presents a particularly interesting architectural solution, connecting the two different and opposing entrances, creating a system of courtyards and atria. Recent documentary acquisitions have made it possible to learn about the design evolution of the building complex, which took place on pre-existing medieval buildings and ancient roadways.

The interior was reorganised in its spaces according to the 'modern' French layout, with rooms, lounges and enfilade galleries that allow the rooms of the flat to be covered according to a circular route. Rooms that, in accordance with the now widespread rocaille taste, were updated by stucco decorations - the work of the Ticino Cantoni.

In the flat on the piano nobile, which now houses the Circolo dei Nobili, there is a small chapel for which a statue by the French sculptor Pierre Puget dedicated to the Immaculate Conception was originally planned, later donated to the nearby Oratory of San Filippo Neri and now replaced - in its original location - by a good interpretation of the same theme by Francesco Maria Schiaffino.