The palace, in its current form, is the result of various building interventions that took place between the sixteenth and nineteenth centuries. Passed in the second half of the seventeenth century to the Negrone, who remain the owners until today, the building was again at the center of a vast renovation at the end of the eighteenth century.

In that period, in fact, the chief of work Antonio Barabino made a general rearrangement of the façade on the square, arrived at its defined arrangement only during the following century. As a result of the arrangement of the area and the opening of Via Carlo Felice (now Via XXV Aprile) between 1825 and 1828, Carlo Barabino created the second access portal, modulated on the architecture of the existing one.

Inside, the palace boasts a remarkable decorative richness with frescoes and decorations commissioned by Agostino Ayrolo.

In the first thirty years of the seventeenth century the first floor was decorated and frescoed according to expedients that refer to the figurative culture of Cortonesca , while around 1700, commissioned by Gio. Antonio Negrone, Domenico Parodi frescoed the ceiling of a room with "The glory of the Negrone family".