The palace was built from 1583 for the two brothers Spinola, Giacomo and Pantaleo, according to a project that combines two specular houses which is accessed from the street by two identical portals, embellished with marble and stone of Finale.

The two twin residences, differ in the interior decorations, commissioned by the various owners who followed each other over time.

In 1624 Lazzaro Tavarone frescoed for the Adorno family businesses in the spaces of the atrium and the main floor; the east body is instead characterized by a nineteenth-century decoration commissioned by the Cattaneo. Recently restored, the palace has been able to recover the decorative layout, defined by illusive architecture, masks and monochrome folder windows.