Built between 1571 and 1578 for Franco Lercari, a powerful Genoese politician and banker at the service of Charles V, the building, thanks to its magnificence, was inscribed in the lists of the “rolli” since 1576, always at the first “bussolo”. It then passed into the possession of the Parodi family in 1845, which still owns the property.

Particularly refined is the treatment of the surfaces also at the ground of the building: treated ashlar, entirely made of Finale stone, is punctuated by pilasters, Doric "rustic" with "diamond-tipped" bosses and opened in correspondence of the marble portal, made by Taddeo Carlone and composed of two frames with noses hubs, direct reference to the singular story that saw protagonist Megollo Lercari, ancestor of the client and mirror of his own virtues and negotiating skills.