At the beginning of the eighties of the sixteenth century Clemente Della Rovere had his palace built in that urban area that connected Piazza Fontane Marose, and then Strada Nuova, with the door of the sixteenth-century wall circuit Acquasola.

Overlooking a small square, the building has a complex architecture, formed by two distinct building units, just as was noted by Pietro Paolo Rubens in the edition of The Palaces of Genoa in 1652.

Became property of Francesco Maria Della Rovere, Doge in 1765-1767, the Palace underwent important reinterpretations in the interior, which were enriched with stucco decorations, "French" furniture and a remarkable collection of paintings of the family. It was at that moment that the client’s refined taste was also taken over by the important foreign personalities visiting the city in those years.

It is currently home to private residences.