It was the first building to open Strada Nuova on the upstream side. The palace was built at the behest of Agostino Pallavicino from 1558 and soon included in the rollo of 1576 to the first “bussolo”.

The work of Bernardino Cantone, although the critics, who for years saw the hand of Galeazzo Alessi, put it in close relationship with the works of the architect Perugia Genoese and Milan. The building faces the street with a façade strongly structured from the architectural point of view.

The refined white marble portal has a broken ribbed pediment that welcomes the shield with the familiar weapon. The usual optical telescope that saw the development, in sequence, of the atrium, courtyard and garden (disappeared after the opening of the vehicular tunnels of Portello) is now distorted by the current setting that the credit institution, current owner, gave the courtyard, closing it to the roof and denying its function as a diaphragm.

Of great interest is the fresco decoration, made by artists called by Pallavicino, Andrea and Ottavio Semino, who worked on the vaults of the living rooms on the ground floor with episodes of ancient history. With the opening of Via Interiano, traced by the architect Ignazio Gardella senior in 1854, the building was cut on one side and covered with a stone and marble vestment modeled on the pre-existing façade.